2024
‘Insights into Mechanisms and Promising Triple Negative Breast Cancer Therapeutic Potential for a Water-Soluble Ruthenium Compound’. N. Nayeem, S. Sauma, A. Ahad, R. Rameau, S. Kebadze, M. Bazett, B.J. Park, P. Casaccia, S. Prabha, K. Hubbard, M. Contel. ACS Pharmacol. Transl. Sci, asap article. https://pubs.acs.org/doi/10.1021/acsptsci.4c00020
‘Development of immunoliposomes containing cytotoxic gold payloads against HER2-positive breast cancers’. A. Ahad, F. Aftab, A. Michel, J.S. Lewis, M. Contel. RSC Med. Chem. 2024, 15, 139-150. https://doi.org/10.1039/D3MD00334E
2023
‘Shifting the Antibody–Drug Conjugate Paradigm: A Trastuzumab-Gold-Based Conjugate Demonstrates High Efficacy against Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Mouse Model’. A. Ahad, H.K. Saeed, V. del Solar, J.E. López-Hernández, A. Michel, J. Mathew, J.S. Lewis, M. Contel. ACS Pharmacol. Trans. Sci. 2023, 6, 12, 1972-1986. https://doi.org/10.1021/acsptsci.3c00270
‘Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models’. J.E. López-Hernández, N. Nayeem, J.P. Cerón-Carrasco, A. Ahad, A. Hafeez, I.E. León, M. Contel. Chem. A Eur. J. 2023, e202302045. Selected as “hot paper” and journal cover. https://doi.org/10.1002/chem.202302045
‘N-Acetylation of Biodegradable Supramolecular Peptide Nanofilaments Selectively Enhances Their Proteolytic Stability for Targeted Delivery of Gold-Based Anticancer Agents’. Y. Marciano, N. Nayeem, D. Dave, R.V. Ulijn, M. Contel. ACS Biomater. Sci. Eng. 2023, 9, 6, 3379-3389. https://pubs.acs.org/doi/10.1021/acsbiomaterials.3c00312
‘5-Nitrofuryl-Containing Thiosemicarbazone Gold(I) Compounds: Synthesis, Stability Studies, and Anticancer Activity’. E. Rodríguez-Arce, E. Gavrilov, X. Alvite, N. Nayeem, I. E. León, M. C. Neary, L. Otero, D. Gambino, C. Olea Azar, M. Contel. ChemPlusChem. 2023. e202300115. Invited Article. Special Collection on Gold Chemistry. https://doi.org/10.1002/cplu.202300115
‘Promising heterometallic compounds as anticancer agents: Recent studies in vivo’. J. E. López-Hernandez, M. Contel. Curr. Opin. Chem. Biol. 2023, 72, 102250. https://www.sciencedirect.com/science/article/pii/S1367593122001351
‘Encapsulation of Gold-Based Anticancer Agents in Protease-Degradable Peptide Nanofilaments Enhances Their Potency’. Y. Marciano, V. del Solar, N. Nayeem, D. Dave, J. Son, M. Contel, R.V. Ulijn. J. Am. Chem. Soc. 2023, 145, 1, 234-246. https://pubs.acs.org/doi/full/10.1021/jacs.2c09820
2022
‘Self-Complementary Zwitterionic Peptides Direct Nanoparticle Assembly and Enable Enzymatic Selection of Endocytic Pathways’. R.H. Huang, N. Nayeem, Y. He, J. Morales, D. Graham, R. Klajn, M. Contel, S. O’Brien, R.V. Ulijn. Adv. Mater. 2022, 34 (1), 2104962.
https://onlinelibrary.wiley.com/doi/10.1002/adma.202104962
2021
‘Intracellular Localization Studies of the Luminescent Analogue of an Anticancer Ruthenium Iminophosphorane with High Efficacy in a Triple-Negative Breast Cancer Mouse Model’. K. Miachin, V. del Solar, E. El Khoury, N. Nayeem, A. Khrystenko, P. Appelt, M.C. Neary, D. Buccella, M. Contel. Inorg, Chem. 2021, 60, 19152-19164. https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c02929
‘Antibody Drug Conjugates Based on Gold Compounds’. M. Contel, N. Curado, J. Lewis, S. Poty. US Patent 11,141,490 (10/12/2021).
‘Investigation of the effects and mechanisms of anticancer action of a Ru(II)-arene iminophosphorane compound in triple negative breast cancer cells’. N. Nayeem N, A. Yeasmin, S.N. Cobos, A. Younes, K. Hubbard, M. Contel. ChemMedChem. 2021., 16, 3280-3292. http://dx.doi.org/10.1002/cmdc.202100325.
‘Exploring the Potential of Metallodrugs as Chemotherapeutics for Triple Negative Breast Cancer’. N. Nayeem, M. Contel. Chem. A. Eur. J. 2021, 27, 8891-8917 https://doi.org/10.1002/chem.202100438
2020
‘Auranofin-Based Analogues Are Effective Against Clear Cell Renal Carcinoma In Vivo and Display No Significant Systemic Toxicity’. B. T. Elie, K. Hubbard, B. Layek, W. S. Yang, S. Prabha, J. W. Ramos, M. Contel. ACS Pharmacol. Transl. Sci. 2020, 3,4, 644. https://doi.org/10.1021/acsptsci.9b00107
‘Sec Hyphenated to a Multielement-Specific Detector Unravels the Degradation Pathway of a Bimetallic Anticancer Complex in Human Plasma’. S. Sarpong-Kumankomah, M. Contel, J. Gailer. J. Chromatogr B., 2020, 1145, 122093. https://www.sciencedirect.com/science/article/pii/S1570023220301197
2019
‘Metal-Based Antibody Drug Conjugates. Potential and Challenges in Their Application as Targeted Therapies in Cancer’. V. Del Solar, M. Contel. J. Inorg. Biochem., 2019, 119, 110780. https://doi.org/10.1016/j.jinorgbio.2019.110780. PDF
‘Preclinical Evaluation of an Unconventional Ruthenium-Gold-Based Chemotherapeutic: RANCE-1, in Clear Cell Renal Cell Carcinoma’. B.T. Elie, K. Hubbard, Y. Pechhenyy, B. Layek, S. Prabha, M. Contel. Cancer Med., 2019, 4304. https://doi.org/10.1002/cam4.2322 (open access). PDF
“Preparation of Titanocene-Gold Compounds Based on Highly Active Gold(I)-N-Heterocyclic Carbene Anticancer Agents: Preliminary in vitro Studies in Renal and Prostate Cancer Cell Lines’ . N. Curado, N. Gimenez, K. Miachin, M. Aliaga-Lavrijsen, M.A. Cornejo, A.A. Jarzecki, M. Contel. ChemMedChem. 2019, 14, 1086. https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201800796
‘Customizing Morphology, Size, and Response Kinetics of Matrix Metalloproteinase-Responsive Nanostructures by Systematic Peptide Design’. J. Son, D. Kalafatovic, M. Kumar, B. Yoo, M.A. Cornejo, M. Contel, R.V. Ulijn. ACS Nano. 2019, 13, 1555. https://pubs.acs.org/doi/abs/10.1021/acsnano.8b07401
‘Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile’. M. Contel. Inorganics. 2019, 7(7), 88. https://www.mdpi.com/books/pdfview/book/1637
‘Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines’. N. Curado, G. Dewaele-Le Roi, S. Poty, J.S. Lewis, M. Contel. Chem. Commun. 2019, 55, 1394. DOI: 10.1039/c8cc08769e.
‘Heterometallic Complexes as Anticancer Agents’. N. Curado, M. Contel. ‘Metal-based Anticancer Agents’ (Series Metallobiology) A, Casini, S. Meier-Menches, A. Vessieres Eds. Royal Society of Chemistry. 2019. https://pubs.rsc.org/en/content/chapter/bk9781788014069-00143/978-1-78801-406-9
‘Bimetallic titanocene-gold phosphane complexes inhibit invasion, metastasis, and angiogenesis-associated signaling molecules in renal cancer’. B.T. Elie, J. Fernández-Gallardo, N. Curado, M.A. Cornejo, J.W. Ramos, M. Contel. Eur. J. Med. Chem. 2019, 161, 310. DOI: 10.1016/j.ejmech.2018.10.034.
2018
‘A heterometallic ruthenium-gold complex displays antiproliferative, antimigratory, and antiangiogenic properties and inhibits metastasis and angiogenesis-associated proteases in renal cancer’. B.T. Elie, Y. Pechenyy, F. Uddin, M. Contel. J. Biol. Inorg. Chem. 2018, 23, 399. DOI: 10.1007/s00775-018-1546-8.
2017
‘Arene ruthenium (II) derivatives containing iminophosphorane ligands and their use in cancer therapy’ M. Contel, I. Marzo, M. Frik, B.T. Elie. US Patent 9555049 (1/31/2017).
2016
‘Auranofin and N-heterocyclic carbene gold- analogs are potent inhibitors of the bacteria Helicobacter. Pylor’i. J.P. Owings, N.N. McNair, Y.F. Mui, T.N. Gustafsson, A. Holmgren, M. Contel, J.B. Goldberg, J.R. Mead. FEMS Microbiol. Lett. 2016, 363, 148. DOI: 10.1093/femsle/fnw148. PDF
‘Titanocene-gold complexes containing N-heterocyclic carbene ligands inhibit growth of prostate, renal and colon cancers in vitro.’ Y.F. Mui, J. Fernández-Gallardo, A. Gubran, B.T. Elie, I. Maluenda, M. Sanaú, O. Navarro, M. Contel. Organometallics, 2016, 35, 1218. DOI: 10.1021/acs.organomet.6b00051. (ACS author choice open access). PDF
‘Titanocene Gold Derivatives Comprising Thiolato Ligands’. M, Contel, J. Fernández-Gallardo, B.T. Elie, J.W. Ramos. US Patent 9,315,531 (04/19/2016). http://https;//patents.justia.com/patent/9315531
‘Synthesis and anticancer activity of carbosilane metallodendrimers based on arene ruthenium (II) complexes’. M. Maroto-Díaz, B.T. Elie, P. Gómez-Sal, J. Perez-Serrano, R. Gómez, M. Contel, F.J. de la Mata. Dalton Trans. 2016, 45, 7049. DOI: 10.1039/C6DT00465B
‘Versatile Synthesis of Cationic N-Heterocyclic Carbene-Gold(I) Complexes Containing a Second Ancillary Ligand. Design of Heterobimetallic Ruthenium-Gold Anticancer Agents’. J. Fernández-Gallardo, B. T. Elie, M. Sanaú, M. Contel. Chem. Commun. 2016, 52, 3155. DOI: 10.1039/C5CC09718E
2015
‘Cyclometalated Iminophosphorane Gold(III) and Platinum (II) Complexes. A Highly Permeable cationic Platinum (II) Compound with Promising Anticancer Properties’. M. Frik, J. Fernández-Gallardo, O. Gonzalo, Victor Mangas-Sanjuan, M. González-Alvarez, A. Serrano del Valle, C. Hu, I. González-Alvarez, M. Bermejo, I. Marzo, M. Contel. J. Med. Chem. 2015, 58, 5825.DOI: 10.1021/acs.jmedchem.5b00427 (ACS author choice open access). PDF
‘Heterometallic titanium–gold complexes inhibit renal cancer cells in vitro and in vivo’ . J. Fernández-Gallardo, B. T. Elie, T. Sadhukha, S. Prabha, M.Sanaú, S.A. Rotenberg, J. W. Ramos, M. Contel. Chem. Sci. 2015, 6, 5269. DOI: 10.1039/C5SC01753J (open access). PDF
‘Design, Synthesis and Characterisation of Chimeric Ruthenium(II)-Gold(I) Complexes showing Enhanced Cytotoxic Properties’. L. Massai, J. Fernández-Gallardo, A. Guerri, A. Arcangelic, S. Pillozzic, M. Contel, L. Messori. Dalton Trans. 2015, 44, 11067. DOI: 10.1039/C5DT01614B.
2014
‘In vitro and in vivo Evaluation of Water-soluble Iminophosphorane Ruthenium(II) Compounds. A Potential Chemotherapeutic Agent for Triple Negative Breast Cancer’. M. Frik, A. Martinez, B.T. Elie, O. Gonzalo, D. Ramirez de Mingo, M. Sanaú, R. Sánchez-Delgado, T. Sadhukha, S. Prabha, J.W. Ramos, I. Marzo, M. Contel. J. Med. Chem. 2014, 57, 9995. DOI: 10.1021/jm5012337
‘Organometallic Titanocene-Gold Compounds as Potential Chemotherapeutics in Renal Cancer. Study of their Protein KInase Inhibitory Properties’. J. Fernández-Gallardo, B.T. Elie, F. Sulzmaier, M. Sanaú, J.W. Ramos, M. Contel. Organometallics. 2014, 33, 6669. DOI: 10.1021/om500965k
‘Auranofin and Related Heterometallic Gold(I)-Thiolates as Potent Inhibitors of Methicillin-Resistant Staphylococcus aureus Bacterial Strains’. Y. Hokai, B. Jurkowicz, J. Fernández-Gallardo, N. Zakirkhodjaev, M. Sanaú, T.R. Muth, M. Contel. J. Inorg. Biochem. 2014, 138, 81. DOI: 10.1016/j.jinorgbio.2014.05.008
‘Luminescent imininophosphorane gold, palladium and platinum complexes as potential anticancer agents’. M. Frik, J. Jimenez, V. Vasilevski, M. Carreira, A. de Almeida, E. Gascon, F. Benoit, M. Sanaú, A. Casini, and M. Contel. Inorg. Chem. Front. 2014, 3, 231. DOI: 10.1039/C4QI00003J
2013
‘Potential Anticancer Heterometallic Fe−Au and Fe−Pd Agents: Initial Mechanistic Insights’. N. Lease, V. Vasileviski, M. Carreira, A. de Almeida, M. Sanaú, P. Hirva, A. Casini, M. Contel. J. Med. Chem. 2013, 56, 5806. DOI: 10.1021/jm4007615
2012
‘Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand as Potential Anticancer Agents’. M. Carreira, R. Calvo-Sanjuán, M. Sanaú, I. Marzo, M. Contel. Organometallics. 2012, 31, 5772. DOI: 10.1021/om3006239
‘Cytotoxic Hydrophilic iminophosphorane coordination compounds of d8 metals. Studies of their Interactions with DNA and HSA’. M. Carreira, R. Calvo-Sanjuán, M. Sanaú, X. Zhao, R. Magliozzo, I. Marzo, M. Contel. J. Inorg. Biochem. 2012, 116, 204. DOI: 10.1016/j.jinorgbio.2012.06.017
‘Luminescent Di and Trinuclear Organometallic Gold(I)-M (Au2, Au2Ag and Au2Cu) Compounds Containing Bidentante Phosphanes as Active Antimicrobial Agents’. M. Frik, J. Jimenez, I. Gracia, L.R. Falvello, S. Abi-Habib, K. Suriel, T.R. Muth, and M. Contel. Chem. A Eur. J. 2012, 18, 3659. DOI: 10.1002/chem.201103145
2011
‘Titanocene-Phosphine Derivatives as Precursors to Cytotoxic Heterometallic TiAu2 and TiM (M = Pd, Pt) Compounds. Studies of their Interactions with DNA’. J.F. González-Pantoja, M. Stern, A.A. Jarzecki, E. Royo, E. Robles-Escajeda, A. Varela-Ramirez, R.J. Aguilera, M. Contel. Inorg. Chem. 2011, 50, 11099. DOI: 10.1021/ic201647h
‘Iminophosphorane-organogold(III) complexes induce cell death through mitochondrial ROS production’. L. Vela, M. Contel, L. Palomera, G. Azaceta, I. Marzo. J. Inorg. Biochem. 2011, 105, 1306. DOI: 10.1016/j.jinorgbio.2011.06.004
‘Group 11 Metal Compounds with Tripodal Bis(imidazole) Thioether Ligands. Applications as Catalysts in the Oxidation of Alkenes and as Antimicrobial Agents’. F. Liu, R. Anis, E. Hwang, R. Ovalle, A. Varela-Ramírez, R.J. Aguilera, and M. Contel. Molecules 2011, 16, 6701. DOI: 10.3390/molecules16086701. Open access publication. PDF
2009
‘Water Soluble Phosphane-Gold(I) Complexes. Applications as Recyclable Catalysts in a Three-Component Coupling Reaction and as Anticancer and Antimicrobial Agents’. B.T. Elie, C. Levine, Iban Ubarretxena-Belandia, A. Varela-Ramirez, R.J. Aguilera, R. Ovalle, M. Contel. Eur. J. Inorg. Chem. 2009, 3421. DOI: 10.1002/ejic.200900279
‘Synthesis of Apoptosis-Inducing Iminophosphorane Organogold(III) Complexes and Study of Their Interactions with Biomolecular Targets’. N. Shaik, A. Martinez, I. Augustin, H. Giovinazzo, A. Varela-Ramirez, M. Sanau, R.J. Aguilera, M. Contel. Inorg. Chem. 2009. 48, 1577. DOI: 10.1021/ic801925k